I would generally say this is not possible in the way you describe it. There are two ways, however, this could be implemented:
1. You use one-time links to content files: all content retrieval URLs will get a parameter expires=X (how long the link should be valid) and a signature (e.g., an HMAC with a secret only known to the NGINX server). Retrieval won't go through mere file access, but a handler that verifies the addtional parameters. If they check out, you redirect to an internal location serving the file.
2. You use a session context: whenever a page validly serving a link to a certain content is delivered, you set a cookie. Retrievals to files require the cookie to be present. No cookie, no access.
Cheers,
--j.