I add my config at server level

#Core Functionality

user nobody;
worker_processes auto;
worker_rlimit_nofile 50000;
thread_pool iopool threads=32 max_queue=65536;
pid /var/run/nginx.pid;
error_log /var/log/nginx/error_log;
#error_log /home/abackup/debug.log debug;

#Load Dynamic Modules
#include /etc/nginx/conf.d/dynamic_modules_custom.conf;

events {
worker_connections 2048;
use epoll;
multi_accept on;
accept_mutex off;
}

#Settings For other core modules like for example the stream module
include /etc/nginx/conf.d/main_custom_include.conf;

#Settings for the http core module
include /etc/nginx/conf.d/http_settings.conf;

***************************

http {

sendfile on;
sendfile_max_chunk 512k;
aio threads=iopool;
directio 50m; #Serve Large files like media files using directio

tcp_nopush on;
tcp_nodelay on;
keepalive_timeout 60;
keepalive_disable msie6 safari;
types_hash_max_size 2048;

server_tokens off;
client_max_body_size 128m;
client_body_buffer_size 256k;
map_hash_bucket_size 128;
map_hash_max_size 2048;

#Tweak timeout settings below in case of a DOS attack
client_header_timeout 1m;
client_body_timeout 1m;
reset_timedout_connection on;

connection_pool_size 512;
client_header_buffer_size 4k;
large_client_header_buffers 4 32k;
request_pool_size 8k;
output_buffers 4 32k;
postpone_output 1460;

#FastCGI
fastcgi_buffers 16 16k;
fastcgi_buffer_size 32k;
# the below options depend on theoretical maximum of your PHP script run-time
fastcgi_read_timeout 300;
fastcgi_send_timeout 300;

server_names_hash_max_size 256000;
server_names_hash_bucket_size 2048;
include /etc/nginx/mime.types;
default_type application/octet-stream;

ssl_protocols TLSv1.2 TLSv1.1 TLSv1;

# Open File Cache
open_file_cache max=8192 inactive=5m;
open_file_cache_valid 5m;
open_file_cache_min_uses 2;
open_file_cache_errors on;

# Logging Settings
open_log_file_cache max=1000 inactive=20s valid=1m min_uses=2;
#Mapping $msec to $sec so that we dont break cPanel bandwidth calculator
map $msec $sec {
~^(?P<secres>.+)\. $secres;
}
log_format bytes_log "$sec $bytes_sent .";
log_not_found off;
access_log off;

# Micro-caching nginx
proxy_cache_path /var/cache/nginx/microcaching keys_zone=micro:20m levels=1:2 inactive=900s max_size=2000m;
proxy_cache micro;
proxy_cache_lock on;
proxy_cache_valid 200 1s;
proxy_cache_use_stale updating;
proxy_cache_bypass $cookie_nocache $arg_nocache;

# GeoIP
# Uncomment to enable
#geoip_country /usr/share/GeoIP/GeoLiteCountry.dat;
#geoip_city /usr/share/GeoIP/GeoLiteCity.dat;

#Limit Request Zone conf
include /etc/nginx/conf.d/limit_request_custom.conf;
#
#CloudFare RealIP conf
include /etc/nginx/conf.d/cloudfare_realip.conf;
#
#FastCGI and PROXY cache config
include /etc/nginx/conf.d/nginx_cache.conf;
#
#Phusion Passenger Setting
include /etc/nginx/conf.d/passenger.conf;
#
#Custom Include File where you can include any custom settings
include /etc/nginx/conf.d/custom_include.conf;
#
# Virtual Host Configs
include /etc/nginx/conf.d/default_server.conf;
include /etc/nginx/sites-enabled/*.conf;
}

**********************************
vhost level
**********************************

location / {
limit_req zone=FLOODPROTECT burst=100;
limit_conn PERIP 125;
limit_conn PERSERVER 500;

proxy_send_timeout 900;
proxy_read_timeout 900;

proxy_buffer_size 32k;
proxy_buffers 16 32k;
proxy_busy_buffers_size 64k;
proxy_temp_file_write_size 64k;

proxy_connect_timeout 300s;

proxy_pass http://PROXYLOCATION;
proxy_set_header Host $host;
proxy_set_header X-Real-IP $remote_addr;
proxy_set_header X-Forwarded-For $proxy_add_x_forwarded_for;
proxy_set_header X-Forwarded-Proto $scheme;
proxy_redirect off;
proxy_set_header Proxy "";
}