After an IRC session in which I assisted Semantic Scuttle developer Christian Weiske to investigate this issue, he provided the following nginx configuration. Christian says it works on debian 8, nginx 1.6.2. I can confirm that also works on Centos 6.6, nginx 1.0.15, the only thing I had to change was the path to the unix socket. Many thanks to Christian for his patience, and for SC in general of course!

Bye,
Marco

(from http://p.cweiske.de/216 )

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server {
listen 80 default_server;
root /var/www/sc/www;
index index.php;
server_name _;

location ~ \.php(/.*)?$ {
# regex to split $uri to $fastcgi_script_name and $fastcgi_path
fastcgi_split_path_info ^(.+\.php)(/.+)$;

# Check that the PHP script exists before passing it
try_files $fastcgi_script_name =404;

# Bypass the fact that try_files resets $fastcgi_path_info
# see: http://trac.nginx.org/nginx/ticket/321
set $path_info $fastcgi_path_info;
fastcgi_param PATH_INFO $path_info;

fastcgi_index index.php;
include fastcgi.conf;
#include snippets/fastcgi-php.conf;
# With php5-fpm:
fastcgi_pass unix:/var/run/php5-fpm.sock;
}
}