I am trying to set-up nginx reverse proxy server with dynamic upstream configuration. The upstream servers are grpc servers, so running over HTTP2. Since http2 uses multiplexing and grpc supports bi-directional streaming, can nginx be configured in below way : a) Every upstream server on start-up will add itself to upstream servers by calling nginx /api and creates a http2 connection with ngby rajatgoyal123 - Nginx Mailing List - English