I use Lighty (lighttpd) on a small VPS where RAM is tight and multiple domains exist. Trading memory for speed, I opt for CGI only, given that FastCGI will consume more memory for each domain (at least that's what I've been told).
I'm looking into NGINX now, and notice that it doesn't support CGI at all. Does anybody know if the combination of NGINX and PHP-FPM has the same side effect? That is, more memory will be consumed for each domain.