Возможно поможет что-то вроде

limit_req_zone $wsgiz zone=wsgi_zone:30m rate=15r/s;
location / {
set $wsgiz binary_remote_addr; #POST
if ($request_method = GET ) {
set $wsgiz $binary_remote_addr$remote_port;#add some random data
}
limit_req zone=wsgi_zone burst=30 nodelay;
uwsgi_pass site_one;
include uwsgi_params;
}

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