I have just set up a Debian Wheezy nginx web server with PHP-FPM and while it shows the hosted websites it doesn't analyse the MIME types and without CSS or JS modern websites are not working.
The problem is the second domain.tld entry:

error.log:

2013/06/22 09:10:46 [error] 7806#0: *1 open() "/var/www/domain.tld/htdocs/domain.tld/wordpress/wp-content/themes/twentytwelve/style.css" failed (2: No such file or directory), client: 5.6.7.8, server: localhost, request: "GET /domain.tld/wordpress/wp-content/themes/twentytwelve/style.css?ver=3.5.1 HTTP/1.1", host: "1.2.3.4", referrer: "http://1.2.3.4/wordpress/"
2013/06/22 09:10:46 [error] 7806#0: *1 open() "/var/www/domain.tld/htdocs/domain.tld/wordpress/wp-content/themes/twentytwelve/js/navigation.js" failed (2: No such file or directory), client: 5.6.7.8, server: localhost, request: "GET /domain.tld/wordpress/wp-content/themes/twentytwelve/js/navigation.js?ver=1.0 HTTP/1.1", host: "1.2.3.4", referrer: "http://1.2.3.4/wordpress/"

How can I fix this?
Thanks

nginx.conf:

user nginx;
worker_processes 4;

error_log /var/log/nginx/error.log warn;
pid /var/run/nginx.pid;

events {
worker_connections 1024;
}

http {
include /etc/nginx/mime.types;
default_type application/octet-stream;

log_format main '$remote_addr - $remote_user [$time_local] "$request" '
'$status $body_bytes_sent "$http_referer" '
'"$http_user_agent" "$http_x_forwarded_for"';

access_log /var/log/nginx/access.log main;

sendfile on;
#tcp_nopush on;

keepalive_timeout 65;

gzip on;

include /etc/nginx/conf.d/*.conf;
}


default.conf

server {
listen 80;
server_name localhost;
root /var/www/domain.tld/htdocs;

#charset koi8-r;
#access_log /var/log/nginx/log/host.access.log main;

location / {
index index.php index.html index.htm;
}

#error_page 404 /404.html;

# redirect server error pages to the static page /50x.html
#
error_page 500 502 503 504 /50x.html;
location = /50x.html {
root /usr/share/nginx/html;
}

##
# Pass PHP-Files To Socket
##

location ~ \.php$ {
try_files $uri =404;
fastcgi_pass unix:/var/run/php5-fpm.sock;
fastcgi_index index.php;
fastcgi_intercept_errors off;
fastcgi_param SCRIPT_FILENAME $document_root$fastcgi_script_name;
include /etc/nginx/fastcgi_params;
}
}